Modern organizations thrive on collaboration, but every file that crosses the network perimeter brings with it potential risk. Whether from trusted partners, customers, or internal teams, files can carry hidden malware that slips past conventional defenses. As file-borne threats move faster and increase in frequency and sophistication, relying solely on endpoint or network detection is no longer enough.
What You're Up Against
According to our findings, file-based attacks remain one of the top three initial infection vectors for cyber incidents. These threats often arrive through:
- Email attachments
- Web or cloud-based file uploads
- Removable media like USB drives
- Cross-border file transfers
What’s more alarming is that 40% of malware evades detection by single-engine antivirus tools, making even seemingly clean files a potential risk. Traditional reactive defenses simply can’t keep up with evasive and zero-day threats.
A New Approach: Secure File Collaboration Without Compromise
OPSWAT recommends a proactive, perimeter-level security model that protects your organization before a file ever reaches your internal environment. The strategy centers around three core pillars:
1. Multiscanning: Strength in Numbers
Instead of relying on one engine, MetaScan™ Multiscanning checks files against 30+ anti-malware engines in parallel, dramatically increasing detection rates and reducing false negatives.
2. Deep CDR™: Remove Threats, Preserve Functionality
Deep CDR sanitizes and regenerates safe-to-use files. By removing macros, scripts, and embedded out-of-policy objects, it disarms threats without altering the file’s usability or format.
3. Seamless Integration
File security must fit into existing infrastructure. MetaDefender integrates via ICAP, REST APIs, and native connectors—so you can enforce file policies at upload portals, cloud storage, email gateways, and beyond, without disruptive changes.
Real-World Impact
The whitepaper outlines how enterprises across critical industries have adopted MetaDefender to:
- Prevent zero-day attacks by sanitizing files before they're opened
- Meet compliance standards such as NERC CIP, HIPAA, and GDPR
- Protect remote workforces and hybrid environments from risky file-sharing practices
One case study highlights how an international bank used MetaDefender to inspect and sanitize millions of files shared across global branches, without interrupting workflow or requiring new hardware.
See It in Action: Watch the Demo
Want to see how MetaDefender neutralizes threats in real time? Watch the demo, which includes a walkthrough of a live file upload and scanning scenario.
On-Demand Webinar: What You'll Learn
In “Secure Files at the Perimeter with Industry-Leading Solutions,” OPSWAT experts break down:
- How to stop known, unknown, and zero-day malware at the perimeter
- How to boost malware detection from ~40% to over 99%
- How to deploy Deep CDR and MetaScan Multiscanning without overhauling your tech stack
- A real-world demo + Q&A with file security specialists

Now is the time to implement multi-layered, defense-in-depth security protocols to not only detect, but prevent threats before they breach your defenses.

Want to dive deeper? We’ve put together a handy buyer’s guide with everything you need to know to find the right solutions for your organization.