Solution
To be able to send notification to your M365 tenant from MetaDefender Core, the following fields should be configured properly under MetaDefender Core:
Server: smtp.office365.com
Port: 587
Connection type: TLS
Auth Method: Auth Login
Email: Email address for sender of notification, it should be a real mailbox which is licensed on M365 side.
Username: username of the mailbox provided under “email” field.
Password: password of the mailbox provided under “Email” field.
More details about M365 URLs can be found checking following link: Microsoft 365 URLs and IP address ranges - Microsoft 365 Enterprise | Microsoft Learn
Example:

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